Optimal Ischemic Lesion Pattern on Brain MRI to Identify Atrial Fibrillation

MVT-AF (multiple vascular territories – atrial fibrillation)

Steven Warach, M.D., Ph.D.

Study Synopsis

This study is the first phase of a three-phase study design aimed at assessing the potential of MRI to identify patients that may have hidden (occult) atrial fibrillation and require stronger anticoagulants than aspirin to prevent stroke. Our hypothesis is that ischemic brain lesions in multiple vascular territories (MVT) are significantly associated with cardioembolic stroke, especially atrial fibrillation (AF). To strengthen the association of this lesion pattern to a cardioembolic source, we will examine relevant clinical data and echocardiographic findings. We will then develop a simple scale to diagnose occult AF based on the MRI and several clinical features. Subsequent phases of the project will test the prediction scale to predict previously undetected AF after stroke and to test the best therapy for stroke prevention.